High Estrogen vs Low Estrogen Symptoms  (For Men)

High Estrogen vs Low Estrogen Symptoms (For Men)

One of the hardest hormones to control while on testosterone replacement therapy is estrogen. This is statement is more true if you’re overweight or have a high BMI count. (All the more reason to start exercising if you’re not already)  Men will sometimes report that their TRT started out great only for it to “stop working” a few months into therapy. Doctors well versed in TRT will likely send you out for an estrogen test and start you on an aromatase inhibitor such as Arimidex if high estrogen is the cause. This powerful drug, if not used correctly however can lead to tanked estrogen levels which come along with symptoms as bad as high E2 levels! The goal is a balance. Let’s take a look at the symptoms of both:

Low Estradiol Symptoms: 

  • Fatigue along the lines of sleepiness
  • hypersomnia (sleeping too much and too often)
  • strong erections but limited sensitivity
  • loss of erections
  • osteoporosis and osteopenia
  • joint pain, clicking or popping joints
  • eye fatigue (eyes seem more tired despite adequate sleep, dark circles)
  • loss of libido (interest in sex)
  • difficulty retaining water (constant urination)
  • anxiety, depression, irritability

High Estradiol Symptoms: 

  • Soft erections, inability to maintain an erection
  • water retention (less frequent urination), leading to excessive sweating, blood pressure spikes or high blood pressure (from the water retention)
  • insomnia
  • hot flushing (flushing around the ears or on the face)
  • night sweats (from estradiol lowering, causing loss of water retention)
  • bloating; brain fog (like your head’s in a bubble)
  • testicles seem smaller than usual


As you can see Estrogen, when not managed correctly, can wreak absolute havoc on the male body. What I’ve found best in all of this is, listen to your body. I’ve had multiple blood tests done, visits to the doctor and without a doubt my body was always telling me what my doctor confirmed. Listen to it. If you have any of the above symptoms get yourself in for a blood test as soon as possible and then speak with your doctor about treatment. (If you’re a cash patient, see my post about how to save money on blood work) If you’re doctor refuses to provide you with the medication you need, switch doctors.

I should note that when my estrogen levels were at their peak (249) I tried to lower them by using a large dose of Arimidex (1mg). I immediately fell into a deep depression not like anything I’d ever experienced before. I’d stopped going to the gym and gained a hefty amount of weight (While Arimidex is supposed to lower bloating, in my case, too much resulted in the exact opposite).

My doctor had mentioned that I needed to lower the fat in my body in order to prevent my testosterone from converting into estrogen. (and rightly so) But I was so exhausted just making it to the grocery store and paying bills was a difficult goal for the day. What a horrible time that was. Thankfully, I’m now on my way to a well balanced controlled schedule of Arimidex and a lower dosage of testosterone.  Within days I started to feel better and I’m back to playing outside with my kids, learning new sheets on the piano, running in the morning and lifting a few weight during the week. It’s also the primary reason I started Dosage May Vary. I wouldn’t wish some of my estrogen symptoms on my worst enemy.

UPDATE 6/14/2017: Since writing this post I no longer use Arimidex. It’s simply far too easy to tank your E2 levels. Arimidex does not work like Tylenol. (Meaning it doesn’t work within hours. Instead it can take days for your E2 levels to drop. Additionally, you may inadvertently cause your E2 levels to “tank”. You may attempt to raise them by giving yourself a higher dose of Testosterone. But this is ultimately a yo yo recipe for disaster. So what’s the best way to manage your E2 levels? Splitting my dosage. I’d read about this many times online but really didn’t want to deal with the hassle of two shots every week. Hindsight is 20/20, it’s the best decision I ever made. I generally no longer have E2 troubles. My energy levels are back to normal, my weight is under control (down almost 30 pounds with exercise!) and my sexual performance is relatively normal. 

Quick Tests You Perform At Home

1. Ring finger test – If you wear a ring and you notice it fitting tighter than normal you are likely bloating. This is usually a pretty good indicator you’re holding onto water which can mean high estradiol.

2. Weight – If you’re weight has gone up especially in the morning you likely have some water retention going on

3. Fatigue – This one is the worst. When my E2 levels were around 249 fatigue was an understatement. I was absolutely shot and could hardly function. I was tired all day even after 8 hours of rest. I’m self employed and that much down time is devastating to my business. If you’re waking up after a good nights rest only to be tired again in a few hours or your eyes seem constantly heavy or tired throughout the day, your estrogen is probably high.

Don’t rely on the home tests, get your bloodwork pulled as soon as possible. This is treatable! Once you’re able to regain your energy levels do your best to eat a healthy diet and bring your weight down. For more on estrogen control visit the Estrogen Control section.



Suicide Hotline: 

  1. When you dial 1-800273-TALK (8255), you are calling the crisis center in the Lifeline network closest to your location. After you call, you will hear a message saying you have reached the National Suicide Prevention Lifeline.

Estrogen can wreak havoc on your body and can lead to major depression. It’s not you, it’s your hormones! Remember this is manageable and can be corrected quickly, see your doctor as soon as possible so he can help address your E2 levels. If you’ve gone into a major depression get into an urgent care, don’t wait for your appointment. 


  • sal Posted August 23, 2016 4:53 am

    In the estrogen symptoms you said fatigue in the lines of sleepenes is a sign of low estrogen, later in the home test you said if you wake up after 8 hr sleep and are tired and fatigue it’s high estrogen.. So fatigue is low or high estrogen????!!!!!!

    • James Posted August 23, 2016 12:26 pm

      Both! The point I was trying to make was that even after a solid 8 hours of sleep, I still felt tired (which isn’t normal) and thus is a sign your E levels are too high. In other words, constant fatigue not remedied by sleep.

    • James Posted June 14, 2017 9:15 pm

      After updating the website, I re-read this comment and realized I did not answer your question very well. I’m going to update this post. While most men report fatigue when their E2 levels were low, my experience it was the opposite. I actually wrote another post about this. I should have (and will) clarify this better in the post above.

      In case you happen to be going through the same thing, I’m actually no longer taking Arimidex. I’ve switch to injecting twice weekly rather than once. This has resulted in less “highs and lows” as well as resolved my E2 issues. The theory behind this method as that you give your body just the right amount of testosterone, thus, lower the chance of conversion. At any rate, for me personally it’s completely resolved any of the prior issues I had. It took about 2 weeks or so for things to balance out but these days I feel pretty normal.

  • Bill culbertson Posted October 14, 2016 10:54 pm

    Hi, I had labs and my doctor told me my T level was 96, I was put on 400mg(2ml) of Watson testosterone injection every 2 weeks. He let me give the shots myself. First 2 weeks I noticed more clarity, I felt pretty good. Then it went down hill. I have taken a total of 4 injections now and feel like crap. Anxiety, really hard to sleep well, zero energy, water retention and skin feels like I used olive oil on my face. I went to Dr today(my regular Dr was off) seen a PA, she kept saying, let’s check your thyroids, do diabetes test, let’s send you for sleep apnea study. I kept telling her, I read many articles online and I need my estrogen level checked. Was ridiculous, I just had a lab done during a physical that tested my blood sugar(was perfect), thyroid tests always been good and I don’t even snore and even asked my wife if she ever heard anything odd when I am sleeping and she said No. Finally the Dr agreed to test my estrogen, so will find out results in 3 days. As I am now, is beyond horrible, I have never had this low energy or anxiety ever.

    • Ray Posted December 15, 2016 7:27 pm

      I am glad you guys posted this. Thank you for sharing. I was on 200mg weekly shots of cypionate. I’ve had the best 6 months after I started the TRT treatment. After this period it went down hill. I noticed I could not sleep and somehow I developed anxiety. I had never experienced anxiety in my entire so this was new and quite shocking to me. I went to my regular doctor and he prescribed anxiety and sleeping pills. It has been a back and forth with my urologist that prescribed the TRT treatment but he’s never even brought up the estrogen topic. To ma things worse I have developed very bad acne in my back and shoulders. I just stopped the cypionate 10 days ago and asked for an estrogen test. I am not against TRT but based on my experience it has to be managed very well with someone that understands all possible angles and not only testosterone shots. I will post my results next week after checking latest lab work. If anyone wants to know more drop me an email.

    • Tj Price Posted January 11, 2017 11:59 am

      Let me know what happened i am going through it now! Iam afraid to do another shot now and Iam going through bad wd’s.

    • B Posted March 28, 2017 1:18 am

      That may be too much testosterone too. For myself the best dosage is 150 a week and I do sub Q which is a lot better and more bang for your buck. It’s also easier too because sub Q is simple and quick. Check your estorgen level but get the ultra sensitive test and not he bogus one that they generally do that is very inaccurate. Check your SBGH too along with prolactin. This should definitely help you get some clarity on what is out of wack! Hope this helps.

  • Jody Baker Posted January 15, 2017 12:05 pm

    What was your diagnosis and result after testing estrogen?

  • Brad W Nichols Posted March 6, 2017 5:30 am

    I’ve been on steroids for 15 year’s, just turned 50 . Noticed something is not right, tired no motivation, I workout at 4 in the morning, missing workouts, no insurance never had blood work done. Currently taking Test DECA Equipoise D bol and then. Taking aromisin when nipples get tinder, take very little time off, cruising right now on 250 test e every week. Please respond worried. Brad thanks

  • Mario Bryant Posted March 19, 2017 2:33 pm

    Diagnosing high blood pressure is usually done during your annual visit to your primary care doctor or the nurse practitioner. They can help get your blood pressure down to a manageable level through medication and recommendations for lifestyle modifications in nutrition and exercise.

  • Pravachol Posted March 23, 2017 12:11 am

    62 you male with multiple issue – insomnia, fatigue, anxiety, low sex drive, dysphagia, chemical sensitivity.
    recent blood work:
    testosterone 640 ng/dL
    free testosterone 6.0 ng/dL (0.9%) low
    SHBG 97 nmol/L high
    estradiol 9 pg/ml low
    Thyroid parameters all in normal range
    Any comments on what might be the upstream cause?

    • Rakshesh Patel Posted April 13, 2017 11:42 am

      For men, normal total estradiol levels are somewhere between 20–55 pg/mL (2.0–5.5 ng/dL) and 10-40 pg/mL (1.0-4.0 ng/dL), depending on who you ask.

    • Frankie J Posted April 18, 2017 3:20 pm

      Your SHBG is way too high. This is the reason your free T is so low. It’s blocking your free T from being available to use by your body. You need to lower that. Also your estrodial is very low. Back off on the estrogen blockers a little. Your body needs some estrogen to function properly. Between 20-30 seems to be the sweet spot for most.

  • Darren Posted October 11, 2017 4:33 pm

    I also had an extremely extremely bad experience with Arimidex. It took me into a depression so unbelievably low and such insomnia and anxiety for weeks and months that I came close to suicide many times. Took almost a year to fully recover, and my doc put me on lexapro. In fact, I think I am now more prone to emotional issues in general since that whole incident 5 years ago. What a fool I was to mess with that stuff.

    DIM is much safer for controlling estradiol in my experience.

    However, I too went the same route as you, splitting the dose into a more reasonable amount like 25-50mg 2x week. And I switched to Test Prop to further reduce estrogen build up.

  • Chad Posted October 17, 2017 7:23 pm

    Hi I hope you still check your board. Thank you for doing this. I was having horrible anxiety and my estrogen was 133. Dr told me to take a half to 1 mg of an AI a day until I feel better. I did this for about three or four days and then stopped because I started getting really tired feeling and I didn’t want my estrogen to tank. I give it about three days and then took a half a pill on one day and then did my normal injection but at a lower dose. They anxiety you came back roaring like crazy so I took again 1 mg I have a milligram another half and now my lower back is hurting so bad I can barely sit. I called them today and ask them to pull blood levels which they did but I won’t have the results for 5 days. If you were me would you to skip the next injection I am till you got the results of your E2 levels? I was going to split my injections twice a week like what you do but I’m scared that it’s the thing Zaidi’s going to come back again it starts getting better after the fourth or fifth day but now the back pain is so bad that I can barely take it I thought it was my kidneys and I wouldn’t have that checked in over everything was normal any suggestions at all would help a bunch thank you

    • James Posted October 17, 2017 7:34 pm

      Yikes, that’s some cry during disney movies level estrogen right there! If your back is starting to ache and your bones are hurting, you’ve already tanked your E2 levels. 1MG a day of Arimidex is a lot. Thing is with Arimidex, is that everyone is different and how much you should take really depends on your size and how big a dose of Test. you are taking.

      I would suggest splitting your dose right now. If your taking 100mg a week, make it 50mg 2x a week etc. Let’s say you normally take it on Monday, then when Monday rolls around take half. Take the other half say Thursday/Friday whatever you feel works best. It’s best to use something like Google Calendar (create a recurring reminder). Because we only have 7 days, each week, your shot is going to be on a different day.

      At any rate, stop taking the Arimidex, split your dosage and wait until things level out. Listen to your body, you’ll know when your estrogen is back to normal. Knowing when it’s too high is pretty easy as well (bloating stomach, sweating while walking around the house, sweating during your sleep more than what would be normal for you, more emotional than usual etc.

      Low E2 is pretty easy to spot. When my E2 is low I’m usually colder than usual around the house, my back starts to ache and I become a bit of a grump ass.

      If you find that your E2 levels are rising again, take 1/4 of 1MG. Wait 1-2 days see how you feel. That’s almost more than enough. I also suggest picking up 30mg of Zinc at Wal Mart and taking that daily for a little while. As ridiculous as it sounds, it really helps with Estrogen control. Be sure to take it with food as it can cause you to become natious on an empty stomach.

  • Chad Posted October 17, 2017 7:24 pm

    That was supposed to say anxiety I’m sorry I did voice to text so some of that probably doesn’t make sense

  • Chad Posted October 18, 2017 2:59 pm

    First of all thank you for responding to my comment so quickly I’m not used to that on these kind of boards . Yeah my estrogen showed on a scale of 5 to 75 below five so wasn’t even traceable so I tanked it bad. I can’t believe how fast ambridex or ai work. I think I took a total of 7 mg. My question is I kind of feel like I’m starting over my testosterone was at 690 so I feel good there I just have the anxiety which I think is from the low estrogen. I want to start splitting my doses up I’m supposed to take 100 mg weekly with my injection day being this Sunday. I’m overweight but I’m working on that I’m currently at 310 pounds but I’ve lost 20 in the last two months and I’m 6 foot one . So based on all that knowledge that you have what do you think would be a good regiment to do especially on the twice a week thing and I’m also starting zinc. One thing I’m kind of scared of is that I got my levels checked at 3:30 in the afternoon which I know you’re supposed to check in the morning so do you think that could give me a false reading? Any advice would help I really appreciate you doing that thank you. Also this was exactly 72 hours after my last injection when I got my blood tested. If the anxiety comes back after I give myself another injection do you have any suggestions on what I should do? I had parathyroid surgery exactly a month ago and they had to take out half my thyroid so I’m getting that tested tomorrow as well would that play in any of this ?thanks again for knowing what you’re talking about and helping other people

  • Chad Posted October 26, 2017 2:29 pm

    Just curious does anyone still reply on this board

  • Dave Posted October 26, 2017 7:27 pm

    Thank you for the interesting read! What caught my eye was frequent urination. I have been suffering which I believe is crash Estrogen from Arimadex. My orginal Total T levels were 86 back in April and now they are 427 taking 25mg of prescribed regulated Clomiphene Citrate everyday. My Estradiol is 16.5 and my sensitive is 18.5.

    I have been battling frequent urination to the point where it feels like I cannot retain water. Since taking Clomid I have been starting to get better but with al the tests I got doctors believe it is hormone related. Cortisol is okay, kidneys are great, bladder is fine. No UTI, or any other bacterial issues.

    I am very lost on what is going on with me. I just want to know how long and what will make me better.

  • Ted Posted November 7, 2017 1:01 pm

    I recently tanked my e2 to <5 using Arimidex. Pretty heavy depression and a constant, crushing migraine. Has anyone else ever had a headache as a result of going too low on e2?

    • James Posted November 7, 2017 1:04 pm

      While I don’t usually have a headache, this is not an uncommon complaint when your E levels drop two low. Drop the Arimidex, keeping taking your text and things should start to balance out after about a week or so.

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